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ISSN: 1553-619X (Print)
ISSN: 1558-3775 (Online)
Research Article Open Access

Immunomodulatory and Antioxidant Properties of Kaurenoic Acid on Macrophages of BALB/c in Vitro

Juliana Aparecida Macri1, Suelen Santos da Silva1, Milena Menegazzo Miranda1, Natalia Yoshie Kawakami1, Thiago Hideki Hayashida1, Tiago Bervelieri Madeira1, Suzana Lucy Nixdorf1, Vinicius Ricardo Acquaro Junior1, Sérgio Ricardo Ambrósio2, Waldiceu Aparecido Verri Jr1, Rubens Cecchini1, Ivete Conchon-Costa1, Nilton Syogo Arakawa1 and Wander Rogério Pavanelli1
  • 1 State University of Londrina, Brazil
  • 2 University of Franca, Brazil

Abstract

Kaurenoic acid has been displaying anti-inflammatory effect described in different models. However, the per se immunomodulatory effects of kaurenoic acid remain to be investigated. Thus, the immunomodulatory and antioxidant effects of kaurenoic acid were investigated in vitro on peritoneal macrophages from BALB/c mice. Kaurenoic acid induced per se the production of pro-inflammatory cytokines such as TNFα, IL-1β and IFN-γ while also increased the levels of IL-10. There was also reduction of NO production and induction of anti-oxidant profile. Therefore, in addition to inhibiting inflammation, kaurenoic acid presents immunomodulatory effects per se.

American Journal of Immunology
Volume 10 No. 4, 2014, 183-188

DOI: https://doi.org/10.3844/ajisp.2014.183.188

Submitted On: 5 February 2014 Published On: 16 February 2015

How to Cite: Macri, J. A., Silva, S. S. D., Miranda, M. M., Kawakami, N. Y., Hayashida, T. H., Madeira, T. B., Nixdorf, S. L., Junior, V. R. A., Ambrósio, S. R., Jr, W. A. V., Cecchini, R., Conchon-Costa, I., Arakawa, N. S. & Pavanelli, W. R. (2014). Immunomodulatory and Antioxidant Properties of Kaurenoic Acid on Macrophages of BALB/c in Vitro. American Journal of Immunology, 10(4), 183-188. https://doi.org/10.3844/ajisp.2014.183.188

Open AccessCopyright: © 2014 Juliana Aparecida Macri, Suelen Santos da Silva, Milena Menegazzo Miranda, Natalia Yoshie Kawakami, Thiago Hideki Hayashida, Tiago Bervelieri Madeira, Suzana Lucy Nixdorf, Vinicius Ricardo Acquaro Junior, Sérgio Ricardo Ambrósio, Waldiceu Aparecido Verri Jr, Rubens Cecchini, Ivete Conchon-Costa, Nilton Syogo Arakawa and Wander Rogério Pavanelli. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • Immunomodulation
  • Kaurenoic Acid
  • Macrophages
  • In Vitro Study