Interleukin-10, Mean Arterial Blood Pressure and Insulin Resistance in Normal Pregnancy

Abstract

Problem statement: The purpose of this study was to investigate whether serum of Interleukin-10 (IL-10) Concentration change during normal pregnancy and, if so, to relate these changes corresponding alterations in insulin resistance and blood pressure. Approach: This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively and in 21 healthy non pregnant women. Serum IL-10 concentration was measured by Enzyme Linked Immunosorbent Assay (ELISA) method. Insulin resistance value was calculated using the homeostasis model assessment, HOMA-IR. Results: Serum IL-10 concentration was found to be significantly higher in patients in all gestational age as compared non pregnant women. Il-10 level was significantly increased with increase in gestational age. Pregnant women exhibited higher score of HOMA IR compared non pregnant women, but there were no difference in this score between pregnant subjects in different gestational age. There were not significant correlation between IL-10 level with IR and blood pressure. Conclusion: The results of the study show maternal IL-10 level increase with further increase in gestational age and there is no significant correlation between IL-10 level with Mean Arterial blood Pressure (MAP) and IR.