Review Article Open Access

DNA Vaccination Associated with Eliminating Inheritance Risks during Embryo Development: A Review

Ria Margiana1
  • 1 Universitas Indonesia, Indonesia

Abstract

The process of immunization using modified DNA is essential whenever scientists desire to trigger an artificial response in the host’s body to improve immunity. The use of DNA vaccines awakens the somatic cells of the host to produce antigens that will assist the body to prepare to fight infections through preventive measures triggered by the vaccines. These biological inventions have assisted in controlling diseases as well as eliminating some health conditions. Scientific analyses have shown how the plasmid DNA could trigger an artificial immune response in living organisms when associated with the antigens that are plasmid-encoded. Such revelations have demonstrated that this invention has a possible therapeutic application as vaccination to prevent numerous pathogens and their related infections. This paper reviews the concept of DNA vaccination and its effects on embryogenesis. The paper first discusses an overview of DNA vaccines and relates it to the production and expression processes. The effects on embryo development have also been described. This review also explains the advantages and disadvantages related to DNA vaccines’ administration and the mechanisms employed to enhance plasmid effectiveness.

OnLine Journal of Biological Sciences
Volume 16 No. 2, 2016, 107-114

DOI: https://doi.org/10.3844/ojbsci.2016.107.114

Submitted On: 15 April 2016 Published On: 26 May 2016

How to Cite: Margiana, R. (2016). DNA Vaccination Associated with Eliminating Inheritance Risks during Embryo Development: A Review. OnLine Journal of Biological Sciences, 16(2), 107-114. https://doi.org/10.3844/ojbsci.2016.107.114

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Keywords

  • DNA Vaccination
  • Embryogenesis
  • Transfection
  • Antibodies
  • Major Histocompatibility Complex (MHC) and Antigen Presenting Cells (APC)