Roles of DLK1 in Liver Development and Oncogenesis
- 1 Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
- 2 Department of Anatomy, Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang, Indonesia
- 3 Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, India
Abstract
Hepato Cellular Carcinoma (HCC) has an increased mortality rate in the last decade. Protein expression in HCC has similarities to the liver cells during the development process. One of the proteins expressions is Delta-Like 1 homolog (DLK1) that was found during liver development and oncogenesis. This permits the opportunity to study pathophysiology and signaling pathway of DLK1 and to find an early detection and therapeutic target for HCC. This review will explain the signalling mechanism and the roles of DLK1 during liver development, oncogenesis of HCC, as a tumor marker and targeting therapy.
DOI: https://doi.org/10.3844/ojbsci.2017.309.315
Copyright: © 2017 Isabella Kurnia Liem, Sibiri Indriyani, Msy Rulan Adnindya and Ahmad Azmi Nasution. This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Keywords
- Hepatocellular Carcinoma
- DLK1
- Liver Development
- HCC Oncogenesis
- Tumor Marker