Research Article Open Access

Studying Interrelation of PDLIM4 with the Model of CD74-Mediated Development of Breast Cancer

Dmitry Sergeevich Kravchenko1, Yuriy Nikolaevich Lezhnin2, Anna Evgenyevna Ivanova1, Yulia Evgenyevna Kravchenko1 and Elena Ivanovna Frolova1
  • 1 Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences 16/10, Miklukho-Maklaya St., GSP-7, Moscow, 117997, Russia
  • 2 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences 119991 Moscow, Russia

Abstract

Mammary gland tumors are often characterized by deregulation of RIL/PDLIM4 expression, however, PDLIM4-mediated mechanisms of cancer development still remain unknown. The aim of our research was to study the influence of PDLIM4-deregulation on transcript me changes of malignized cells. We performed а comparative NGS-analysis of breast cancer cell lines with suppressed and induced expression of PDLIM4 and identified a number of genes, whose expression correlated with PDLIM4 level. Among them we found CD74 gene, which is known as a potential marker of triple negative subtype of breast cancer. The obtained results allowed us to propose an interrelation between PDLIM4 and the CD74-mediated mechanism of breast cancer development and to analyze the correlation of PDLIM4 with the main components of CD-74-dependent model.

OnLine Journal of Biological Sciences
Volume 17 No. 2, 2017, 50-57

DOI: https://doi.org/10.3844/ojbsci.2017.50.57

Submitted On: 16 February 2017 Published On: 3 June 2017

How to Cite: Kravchenko, D. S., Lezhnin, Y. N., Ivanova, A. E., Kravchenko, Y. E. & Frolova, E. I. (2017). Studying Interrelation of PDLIM4 with the Model of CD74-Mediated Development of Breast Cancer. OnLine Journal of Biological Sciences, 17(2), 50-57. https://doi.org/10.3844/ojbsci.2017.50.57

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Keywords

  • Breast Cancer
  • PDLIM4-Mediated Mechanisms
  • Malignized Cells