Potential Pathomechanism of Neuro-COVID-19
- 1 Cadi Ayyad University, Morocco
- 2 University Hospital Mohamed VI, Morocco
Abstract
Gathered data about SARS-CoV-2 have shown strong evidence in terms of neuroinvasive and neurotropic capacities of the virus to reach and cause eventual damage to the Central Nervous System. The spread of the virus may occur through direct and indirect ways, leading to anosmia and/or ageusia. These signs have been observed in many COVID-19 patients and are then included in the diagnostic criteria for Neuro-COVID-19. The invasion of SARS-CoV-2 into the dorsal vagal complex of the brainstem has a harmful impact on the respiratory rhythm, with even respiratory failure. There is evidence that immune response abnormalities including cytokine storm and neuro-inflammation influence not only the disease severity, but also the occurrence of neurological and neurodegenerative manifestations. Many umbrella zones remain unclear about Neuro-COVID-19, which requires more consideration in its clinical, biological and therapeutic aspects and may open new research perspectives.
DOI: https://doi.org/10.3844/ojbsci.2020.232.238
Copyright: © 2020 Abir Fguirouche, Nissrine Louhab, Mohamed Chraa, Najib Kissani and Brahim Admou. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- 3,434 Views
- 1,475 Downloads
- 0 Citations
Download
Keywords
- Sars-CoV-2
- COVID-19
- Nervous System
- Pathomechanisms
- Cytokine Storm