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Frequency: Quarterly
ISSN: 1608-4217 (Print)
ISSN: 2410-8561 (Online)
Literature Review Open Access

A Review of Cellular Mechanism of Pulsed Electromagnetic Field (PEMF) in Inhibiting Adipogenesis of Mesenchymal Stem Cells

Puji Sari1, Nuzli Fahdia Mazfufah2, Umiatin3, Dwi Anita Suryandari1, Silvia Werdhy Lestari1 and Luluk Yunaini1
  • 1 Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • 2 Department of Stem Cells and Tissue Engineering Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • 3 Departement of Physics, Universitas Negeri Jakarta, Jakarta, Indonesia

Abstract

PEMF is a method that utilizes electric current using a coil that is powered by dynamic electric current, it will cause a dynamic magnetic field in the coil. In the last few decades, it is known that PEMF has the potential to be used as a modality in the treatment of obesity. For this reason, PEMFs have been studied in vitro as their effect in inhibiting the adipogenesis of Mesenchymal Stem Cells (MSC). But the use of PEMF therapy in inhibiting adipogenesis still has many challenges. Understanding of the mechanisms that occur in cells that are exposed to PEMF is also still very slight. This article reviews the studies that investigated in vitro effect of PEMF in inhibiting adipogenesis studies and the underlying mechanism. In the future, it is hoped that this review can be used as a basic reference for in vivo research and clinical trials related to inhibiting adipogenesis using PEMF.

OnLine Journal of Biological Sciences
Volume 23 No. 2, 2023, 177-186

DOI: https://doi.org/10.3844/ojbsci.2023.177.186

Submitted On: 4 August 2022 Published On: 26 March 2023

How to Cite: Sari, P., Mazfufah, N. F., Umiatin, Suryandari, D. A., Lestari, S. W. & Yunaini, L. (2023). A Review of Cellular Mechanism of Pulsed Electromagnetic Field (PEMF) in Inhibiting Adipogenesis of Mesenchymal Stem Cells. OnLine Journal of Biological Sciences, 23(2), 177-186. https://doi.org/10.3844/ojbsci.2023.177.186

Open AccessCopyright: © 2023 Puji Sari, Nuzli Fahdia Mazfufah, Umiatin, Dwi Anita Suryandari, Silvia Werdhy Lestari and Luluk Yunaini. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • Obesity
  • PEMF
  • Adipogenesis
  • MSC