Impact of Coriander Seeds Extract Against Thyroidectomy Induced Testicular Damage and DNA Replication in Male Rats

Abstract

An important target organ for thyroid hormone activity is the testis and hypo or hyperthyroidism causes noticeable alterations in testicular function. This study aimed to investigate the therapeutic effect of Coriander Seeds Extract (CSE) against thyroidectomy induced toxicity, oxidative stress, injury, and proliferation in male testes rats. 40 male rats were equally divided into 4 groups [Gp1, control; Gp2, CSE; Gp3, thyroidectomies rats (Thy); Gp4, treated thyroidectomies rats with coriander (Thy + CSE)]. Current results revealed after 3 weeks of thyroidectomy; a significant (p<0.05) elevation in TSH, total T₄, serum AST, and serum ALP, non-progressive motility and immotile sperms, testicular MDA, testicular injury, and a significant (p<0.05) reduction in total T₃, sexual hormones (testosterone, FSH, LH, and prolactin), sperms parameters (count, morphological index, vitality, total and progressive motility), testicular GSH, testicular SOD, and testicular GST and PCNA expressions when compared with control. Thy + CSE modulates most of changes parameters and recovery the testicular injury. We can conclude that; coriander seed extract could enhance the testis against thyroidectomy produced toxicity and oxidative stress in testes through its positive effects in scavenging free radicals.