Orlistat Induce Renal Toxicity, DNA Damage, and Apoptosis in Normal and Obese Female Rats

Abstract

Obesity has been linked to several chronic diseases, including fatty liver disease, fatty heart disease, diabetes mellitus, hypertension, obstructive sleep apnea, and cancer. The purpose of the current study was to determine how Orlistat affected renal toxicity, DNA damage, and apoptosis that were brought on by obesity in normal and obese female rats. There were four groups made up of a total of 20 female rats (G1, Control; G2, Orlistat; G3, Obesity; G4, treated obesity with Orlistat rat group). The results of the present investigation showed that orlistat treatment resulted in kidney injury, DNA damage, and P53 mutations as well as a large increase in serum urea and creatinine levels as well as a significant drop in sodium, potassium, calcium, and chloride ions levels. Therefore, when administered to treat normal or obese rats, orlistat caused kidney damage; as a result, doctors should carefully monitor it.