Subfractions of Low-Density-Lipoprotein: Which is the Most Atherogenic?

Abstract

Atherosclerosis is a widespread disease of the arteries, which manifests itself in the narrowing of the lumen of the vessel due to the formation of plaque on its walls. Despite an impressive history of study, atherosclerosis still leaves room for researchers. This is realized due to the complexity of pathogenesis, in which important roles are assigned to a variety of processes at all levels, from mitochondrial disorders to endothelial dysfunction. However, it is customary to pay the most attention to lipids, since, according to modern concepts, it is the modifications of lipid particles, namely LDL, that are a prerequisite for the development of atherosclerosis. In this review, we have collected data on the subfractions of this group of lipids, namely their atherogenicity. One of the central issues in the diagnosis and prevention of atherosclerosis is the measurement of atherogenicity.