Research Article Open Access

The Association of Blood Serum Atherogenicity with Risk Factors for Cardiovascular Disease

Tatiana Vladimirovna Kirichenko1,2, Igor Alexandrovich Sobenin1,2, Veronika Alexandrovna Myasoedova3, Andrey Vladimirovich Omelchenko2, Sergey Gennadyevich Kozlov4 and Alexander Nikolaevich Orekhov2,5
  • 1 Laboratory of Medical Genetics, Chazov National Medical Research Center of Cardiology, Ac. Chazov Str. 15A, Moscow, Russia
  • 2 Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow, Russia
  • 3 Centro Cardiologico Monzino IRCCS, Str. Carlo Parea 4, Milan, Italy
  • 4 Department of Atherosclerosis Problems, Chazov National Medical Research Center of Cardiology, Ac. Chazov Str. 15A, Moscow, Russia
  • 5 Department of Atherosclerosis, Institute for Atherosclerosis Research, Str. Osennyaya 4, Moscow, Russia

Abstract

Cardiovascular Diseases (CVD) caused by atherosclerosis are the most frequent cause of mortality worldwide, so the identification of new biomarkers of atherosclerosis development is quite actual. The atherogenicity of blood serum is considered as the potential of human serum to cause cholesterol accumulation in primary culture macrophages. The current study aimed to evaluate the association of the atherogenicity of blood serum with conventional cardiovascular risk factors to assess its potential in CVD prognosis. Serum atherogenicity was measured in 815 study CVD-free participants at baseline and at the follow-up visit after 5 years. 51% of study participants had atherogenic serum at baseline, but at the follow-up visit after 5 years atherogenicity increased significantly in 60% of participants. An increase of atherogenicity was observed in the group with non-atherogenic serum at baseline, p<0.001. The correlation of serum atherogenicity with plasma lipids level, i.e., total cholesterol and LDL, was demonstrated. There was a negative correlation between changes in the potential of blood serum to induce cholesterol accumulation in primary culture macrophages and the age of study participants (r = -0.089, p = 0.011). In groups with decreased and unchanged atherogenicity, the increase of statin administration, as well as amelioration of lipids profile, were revealed after a 5-year follow-up. Thus, the atherogenicity of blood serum may be considered a promising marker in the prognosis of CVD development, but further research is needed to evaluate the prognostic value of serum atherogenicity.

OnLine Journal of Biological Sciences
Volume 24 No. 1, 2024, 24-31

DOI: https://doi.org/10.3844/ojbsci.2024.24.31

Submitted On: 9 June 2023 Published On: 30 October 2023

How to Cite: Kirichenko, T. V., Sobenin, I. A., Myasoedova, V. A., Omelchenko, A. V., Kozlov, S. G. & Orekhov, A. N. (2024). The Association of Blood Serum Atherogenicity with Risk Factors for Cardiovascular Disease. OnLine Journal of Biological Sciences, 24(1), 24-31. https://doi.org/10.3844/ojbsci.2024.24.31

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Keywords

  • Atherosclerosis
  • Serum Atherogenicity
  • Intracellular Cholesterol Accumulation
  • Cardiovascular Risk Factors