Review Article Open Access

Long Way of Evaluating Niacin for Atherosclerosis Treatment

Anastasia Vladimirovna Poznyak1, Victoria Alexandrovna Khotina2, Elizaveta Mikhailovna Pleshko3, Vasily Nikolaevich Sukhorukov3, Victor Yurievich Glanz3 and Alexander Nikolaevich Orekhov3
  • 1 Laboratory of Angiopathology, Institute for Atherosclerosis Research, Moscow, Russia
  • 2 Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, Moscow, Russia
  • 3 Laboratory of Cellular and Molecular Pathology of Cardiovascular System, Petrovsky National Research Centre of Surgery, Moscow, Russia

Abstract

Atherosclerosis is a significant public health challenge, as it is closely associated with a wide range of cardiovascular diseases and complications. Despite its grave implications, the timely detection and treatment of atherosclerosis remain complex tasks due to the intricate pathogenesis involved, which encompasses numerous processes and mechanisms. Extensive research has been conducted to investigate various therapeutic methods and drugs aimed at targeting both the overall progression of the disease and specific pathogenic mechanisms. Recognizing the multifaceted nature of atherosclerosis, comprehensive treatment approaches have emerged as essential in effectively managing the condition. This review provides a thorough examination of the mechanisms underlying the action of niacin, a potential therapeutic agent, in the treatment of atherosclerosis. By illuminating the specific modes of action of niacin, this review contributes to our understanding of its promising role as a treatment modality for atherosclerosis and offers insights into its potential clinical applications.

OnLine Journal of Biological Sciences
Volume 24 No. 3, 2024, 349-357

DOI: https://doi.org/10.3844/ojbsci.2024.349.357

Submitted On: 26 November 2023 Published On: 24 February 2024

How to Cite: Poznyak, A. V., Khotina, V. A., Pleshko, E. M., Sukhorukov, V. N., Glanz, V. Y. & Orekhov, A. N. (2024). Long Way of Evaluating Niacin for Atherosclerosis Treatment. OnLine Journal of Biological Sciences, 24(3), 349-357. https://doi.org/10.3844/ojbsci.2024.349.357

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Keywords

  • Niacin
  • Drug Evaluation
  • CVD
  • Atherosclerosis