Morphological Changes in Brain Tissue During Experimental Hypoxia

Abstract

The extensive application of hypoxic training to enhance cerebral circulation highlights its significant role in effectively realizing the therapeutic and health-promoting benefits of this method. The discrepancy between the data on the features of cerebral circulation and cellular metabolism in brain tissues during circulatory hypoxia and significant interest in the physiological patterns of the integrative response of the body determined the feasibility of this study. Hypoxic training is widely used in sports and rehabilitation medicine and it is relevant to study the adaptation mechanisms of this condition. To study the morpho-functional features of cerebral circulation, brain tissue after experimental hypoxic normobaric training. The experiments involved Sprague Dawley rats, which were placed in a hypoxic chamber for 45 minutes daily over periods of 15 and 30 days. Morphological and physiological assessments were performed. Blood flow velocity in the middle cerebral artery of the experimental animals was measured using ultrasound Doppler imaging. A cycle of hypoxic training led to a decrease in the rhythmic (pulse) index and an increase in the functional activity of cells, indicating the expression of cerebral vascular responses and an increase in cerebral blood flow velocity. To safeguard the brain from hypoxia, robust mechanisms regulating cerebral circulation enhance blood flow to compensate for the reduced oxygen levels in arterial blood. The data of this study showed that hypoxic training leads to an increase in brain metabolism and an improvement in cerebral circulation, which is an adaptive response of the cardiorespiratory system of the body after hypoxic training.