@article {10.3844/ajbbsp.2026.22.01.015,
article_type = {journal},
title = {Cytocompatibility and Antimicrobial Properties of Silver Nanoparticles-Loaded AMPs in the Oral Cavity},
author = {Lv, Yanli and Zhang, Weikai},
volume = {22},
number = {1},
year = {2026},
month = {Apr},
pages = {15-1},
doi = {10.3844/ajbbsp.2026.22.01.015},
url = {https://thescipub.com/abstract/ajbbsp.2026.22.01.015},
abstract = {Postoperative infection following oral metal implantation is a key factor that affects the success rate of surgery. This infection is mainly caused by bacterial biofilms. Traditional single antibacterial coatings have limitations, including a narrow antibacterial spectrum and poor cytotoxicity or stability. This study combined silver nanoparticles (AgNPs) and the synthetic antimicrobial peptide GL13K using electrostatic self-assembly technology to create a dual-effect antimicrobial coating. The AgNPs were prepared using the chemical reduction method, and the GL13K nanofibers were formed through β-folding self-assembly. These processes utilized their complementary charge characteristics to achieve a precise composite. The experimental results showed that the antibacterial rate of the coating against streptococcus pneumoniae, pseudomonas aeruginosa, and MRSA was significantly higher than that of a single coating (reducing CFU by 2-3 orders of magnitude, p0.05). The effect of different nanoconcentrations and coating temperature on antibacterial activity was not statistically significant (p>0.05). This study addresses the limitations of traditional coatings by using a collaborative, nanoscale design approach to provide a new strategy for optimizing the antibacterial properties of oral implant materials.},
journal = {American Journal of Biochemistry and Biotechnology},
publisher = {Science Publications}
}